Mycobacterium scrofulaceum is one of the slowly growing scotochromogenic nontuberculous mycobacteria. In adult, the clinical manifestations of M. scrofulaceum infections include pulmonary disease, hepatitis, osteomyelitis, and cutaneous infection. Herein, we report a rare case of disseminated M. scrofulaceum infection in a patient with lymphoma. The patient had the M. scrofulaceum infections that involved lung and joint, and the clinical condition responded to the antimycobacterial agent and surgical debridement well.