7700 E Arapahoe Rd., Centennial, 80112-1268, CO, USA medicalresearch@onlinescientificresearch.info


International Scientific Indexing (ISI) Indexed Journal Applied Medical Research ISSN: 2149 - 2018
Applied Medical Research. 2016; 4(2):(43-138)


In vitro antimicrobial potential of potentilla polyphylla Wall. ex Lehm. taproot extract against human pathogens

Khonamai Sewa Nakhuru, Jyotchna Gogoi, Pronobesh Chattopadhyay, Hemanta Kumar Gogoi

Abstract
Background: The whole plant of Potentilla polyphylla Wall. ex Lehm. (Rosaceae) is valued for its ethno-medicinal properties. It has been used as a folk remedy against a variety of ailments. Aim: This study aimed to assess the antimicrobial potential of P. polyphylla taproot extract against human pathogens. Methods: The antimicrobial activity of the aqueous methanol extract (1:4) against bacterial strains and clinically important yeast were assessed using the agar diffusion assay and minimum inhibitory concentration studies. Its effect was compared with some standard antibiotics. Results: The extract showed inhibition of 17.5-30.0 mm and minimum inhibitory concentrations of 0.01 mg/ml and 0.4 mg/ml against Streptococcus mutans and Candida albicans, respectively. Tested pathogens, except P. mirabilis, were found susceptible to standard antibiotics. Conclusions: Results showed that P. polyphylla possesses broadspectrum antimicrobial properties and hence merits detailed phytochemical investigations for its pharmaceutical applications.